Authors
Auda Nadira ^1,3, Sunita Sunita ^3,4,6, Bima Diokta Alparisi^3,7, Amanda Cheryl Fayza^3,5, Nur Syifa Rahmatika^1,3, Putri Karisa^3,4, Nova Sylviana^2,3 and Mas Rizky A.A Syamsunarno^2,3

Affiliations

¹Master Study Program of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia

²Department of Biomedical Sciences, Faculty of Medicine Universitas Padjadjaran, Bandung, West Java, Indonesia

³Cardiometabolic Working Group Study, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia

⁴Doctoral Program, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia

⁵Bachelor Study Program, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia

⁶Department of Medical Laboratory Technology, Poltekkes Kemenkes Bengkulu, Bengkulu, Indonesia

⁷Clinical Professional Program, RSUD Arifin Achmad, Faculty of Medicine, Universitas Riau, Pekanbaru, Riau, Indonesia

Background

• Major adverse cardiovascular events (MACE) remain a leading cause of poor prognosis after acute myocardial infarction (AMI).

• Adipokines from fat tissue may add cardiometabolic risk information beyond conventional measures.

Methods

• Systematic review and meta-analysis of adiponectin and visfatin levels in adult AMI patients with and without MACE.

• Five cohort studies (707 patients) from China, Taiwan, Japan, and Poland were included.

Key Results

• Adiponectin levels were lower in patients who had MACE.

• Visfatin levels were significantly higher in the MACE group.

Discussion & Conclusion

• Lower adiponectin and higher visfatin are associated with MACE after AMI.

• BMI did not show significant discriminatory value.

Related SDGs

SDG 3: Good Health and Well-Being – Improving risk prediction after heart attack

Journal Information

Journal: BMC Cardiovascular Disorders

DOI: https://doi.org/10.1186/s12872-026-06120-0

Background

• People with drug-resistant TB (DR-TB) make multiple healthcare visits before diagnosis and treatment.

• This study quantified pretreatment direct costs and the factors linked to higher costs.

Methods

• Cross-sectional study at three DR-TB referral centers in Bandung (February 2023–February 2024).

• 258 adults with pulmonary DR-TB were interviewed about their out-of-pocket costs.

• Costs were analysed descriptively, and quantile regression identified factors linked to higher costs.

Key Results

• The median pretreatment direct cost was USD 44.6 per person (excluding hospitalization).

• Major contributors were hospitalization ($67.3), travel ($13.7), chest radiography ($11.2), and medication ($10.8).

• Higher costs were linked to rural residence, seven or more provider visits, and a first visit to a hospital or private primary care.

Discussion & Conclusion

• People with DR-TB in Indonesia incur substantial costs before treatment even begins.

• Stronger TB diagnostic infrastructure and public–private sample referral networks in rural areas can reduce extra visits and financial burden.

Related SDGs

SDG 1: No Poverty – Easing the financial burden on patients and families

SDG 3: Good Health and Well-Being – Reducing barriers to drug-resistant TB care

Journal Information

Journal: PLoS ONE
DOI: https://doi.org/10.1371/journal.pone.0352658

Background

• Acute inability to flex the knee after a sudden extension event is usually attributed to structural damage.

• Some patients have non-mechanical limitation that resolves without invasive treatment.

Methods

• Narrative review and conceptual synthesis on arthrogenic muscle inhibition, knee effusion, and rotational knee biomechanics.

• Combined with clinical observations to build a bedside assessment framework.

Key Results

• A four-component framework: (1) aspirate knee effusion; (2) assess gravity-assisted passive flexion; (3) pain-limited, alignment-facilitated motion; (4) confirm restoration of symmetric motion.

Discussion & Conclusion

• Acute knee flexion limitation may not always reflect fixed mechanical obstruction.

• The framework is hypothesis-generating and needs prospective clinical validation.

Related SDGs

1. SDG 3 – Good Health and Well-Being
The article addresses an orthopedic clinical problem and proposes a framework to improve clinical assessment and management of acute knee flexion limitation. It aims to support clinical reasoning and potentially improve patient care, although the framework still requires prospective validation.

2. SDG 9 – Industry, Innovation and Infrastructure
The article presents a new conceptual clinical framework integrating effusion-mediated inhibition and rotational knee biomechanics. However, it does not develop a new medical technology, device, or infrastructure.

Journal Information

Journal: Orthopedic Research and Reviews

DOI: https://doi.org/10.2147/ORR.S621455

Authors
Yovita Hartantri¹ | Sherly Lawrensia² | Steven Yulius Usman³ | Nenny Agustanti⁴ | Rudi Wisaksana¹ | Nanny Natalia Mulyani Soetedjo⁵ | Bachti Alisjahbana¹

Affiliations

¹Division of Tropical and Infectious Diseases, Department of Internal Medicine, Hasan Sadikin General Hospital, Faculty of Medicine, Universitas Padjadjaran, West Java, Indonesia | ²Department of Internal Medicine, Hasan Sadikin General Hospital, Faculty of Medicine, Universitas Padjadjaran, West Java, Indonesia | ³School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia | ⁴Division of Gastroenterohepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, West Java, Indonesia | ₅Division of Endocrine and Metabolism, Department of Internal Medicine, Hasan Sadikin General Hospital, Faculty of Medicine, Universitas Padjadjaran, West Java, Indonesia

Background

• People living with HIV (PLWH) now live longer, so chronic conditions matter more.

• Dyslipidemia and other metabolic risks for MASLD (metabolic dysfunction-associated steatotic liver disease) are common in PLWH.

Methods

• Systematic review and meta-analysis following PRISMA, registered in PROSPERO.

• Seven databases searched; 17 studies with 3,933 HIV-positive participants were included.

• Mean differences were calculated using a random-effects model.

Key Results

• 1,226 participants (37%) had MASLD.

• Male sex and higher BMI were associated with MASLD.

• MASLD patients had higher total cholesterol, LDL, and triglycerides, and lower HDL.

Key Results

• 1,226 participants (37%) had MASLD.

• Male sex and higher BMI were associated with MASLD.

• MASLD patients had higher total cholesterol, LDL, and triglycerides, and lower HDL.

Discussion & Conclusion

• PLWH who develop MASLD show a distinct lipid profile.

• This may represent a metabolic signature of the condition.

Related SDGs

SDG 3 – Good Health and Well-Being

The study focuses directly on HIV, MASLD, metabolic disorders, lipid abnormalities, screening, early intervention, and long-term health outcomes. The authors specifically conclude that routine lipid assessment and targeted MASLD screening are important components of HIV care.

SDG 10 – Reduced Inequalities

The research specifically concerns people living with HIV (PLWH), a population requiring particular attention in healthcare. The article also examines differences across sex, ethnicity, and geographical regions, although these factors were not the main intervention or objective of the study

Journal Information

Journal: Chronic Diseases and Translational Medicine

DOI: https://doi.org/10.1002/cdt3.70028