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Trends in adipokine-related studies in cardiovascular disease: A bibliometric analysis from 2002 to 2024

by gita sonia | Sep 22, 2026 | Artikel, SDG 17, SDG 3, SDGS

Authors
Sunita Sunita, Dr.^1,4,7, Mohammad Rizki Akbar, Dr.^2,4, Mohammad Ghozali, Dr.^3,4, Iis Inayati Rakhmat, Dr.^4,5, Agung Riyadi, MPH⁶, Annisa Dewi Nugrahani, MSc.¹, Ratih Rinendyaputri, Dr.⁸, Gaga Irawan Nugraha, Dr.^3,4, Mas Rizky A A Syamsunarno, Dr.^3,4Affiliations
¹Faculty of Medicine Universitas Padjadjaran, Bandung, West Java, Indonesia, ²Department of Cardiology and Vascular

Medicine, Hasan Sadikin General Hospital-Faculty of Medicine Universitas Padjadjaran, Bandung, West Java, Indonesia,

³Department of Biomedical Sciences, Faculty of Medicine Universitas Padjadjaran, Bandung, West Java, Indonesia,

⁴Cardiometabolic Working Group Study, Faculty of Medicine Universitas Padjadjaran, Bandung, West Java, Indonesia,

⁵Department of Biochemistry, Faculty of Medicine, Jenderal Achmad Yani University, Kota Cimahi, Jawa Barat, Indonesia,

⁶Department of Nursing, Poltekkes Kemenkes Bengkulu, Bengkulu, Indonesia, ⁷Department of Medical Laboratory Technology,

Poltekkes Kemenkes Bengkulu, Bengkulu, Indonesia, 8Center for Biomedical Research, National Research and Innovation

Agency (BRIN), Cibinong Science Centre, Cibinong, West Java, Indonesia.

Background

• Adipokines are proteins secreted by fat tissue and are linked to obesity, inflammation, and cardiovascular disease (CVD).

• Bibliometric analysis can map research trends and international collaboration.

Methods

• Bibliometric analysis of Scopus publications from 2002 to 2024.

• Data were analysed with Biblioshiny and VOSviewer.

Key Results

• 1,283 documents from 602 sources were included.

• Output rose substantially from 2002 and peaked around 2013–2014.

• Obesity, adiponectin, leptin, inflammation, and metabolic dysfunction were dominant themes; the United States led in output, citations, and collaboration.

Discussion & Conclusion

• Research on adipokines and CVD has expanded substantially over two decades.

• The findings may help identify future priorities on adipokines as biomarkers, preventive targets, and therapeutic approaches.

Related SDGs

SDG 3: Good Health and Well-Being – Mapping research on cardiovascular disease

SDG 17: Partnerships for the Goals – Highlighting international research collaboration

Journal Information

Journal: Medical Journal of Malaysia

DOI: Not available (no DOI listed for this article)

Recent Insights Into Circulating Adipokines in Obesity: Systematic Review and Meta‐Analysis

by gita sonia | Sep 22, 2026 | Artikel, SDG 3, SDGS

Affiliations

¹ Doctoral Program, Faculty of Medicine Universitas Padjadjaran, Bandung, West Java, Indonesia | ² Cardiometabolic Working Group Study, Faculty of Medicine Universitas Padjadjaran, Bandung, West Java, Indonesia | ³ Department of Medical Laboratory Technology, Poltekkes Kemenkes Bengkulu, Bengkulu, Indonesia | ⁴ Department of Biomedical Sciences, Faculty of Medicine Universitas Padjadjaran, Bandung, West Java, Indonesia |⁵ Department of Cardiology and Vascular Medicine, Hasan Sadikin General Hospital‐Faculty of Medicine Universitas Padjadjaran, Bandung, West Java, Indonesia | ⁶ Department of Biochemistry, Faculty of Medicine, Jenderal Achmad Yani University, Cimahi, Jawa Barat, Indonesia | 7 Department of Public Health, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia

Background

Adipokines are dysregulated in obesity and worsen pro-inflammatory conditions.
Previous findings on adipokine levels in obesity have been inconsistent.

Methods

Systematic review and meta-analysis (PROSPERO CRD42024525103) of adiponectin, leptin, FGF21, GDF15, IL-6, and TNF-α.
Searches to August 25, 2025; 30 studies in the review and 16 in the meta-analysis, using a random-effects model.

Key Results

Adiponectin was significantly lower in people with obesity.
Leptin, TNF-α, and FGF21 were significantly higher.
No significant differences were found for GDF15 and IL-6.

Discussion & Conclusion

Adiponectin, leptin, TNF-α, and FGF21 show consistent patterns and may serve as biomarkers for obesity-related risk profiling.
GDF15 and IL-6 vary by context, and further prospective cohort studies are needed.

Related SDGs

SDG 3: Good Health and Well-Being – Advancing biomarkers for obesity-related disease risk

Journal Information

Journal: Obesity Science and Practice

DOI: https://doi.org/10.1002/osp4.70113

Predictors of functional ability in autism spectrum disorder: A scopingreview

by gita sonia | Sep 22, 2026 | Artikel, SDG 10, SDG 3, SDGS

Authors
Purboyo Solek^a*, Eka Nurfitri^a, Taufan Prasetya^a, Anggia Farrah Rizqiamuti^a, Indra Sahril^a, Burhan^a, Uni Gamayani^b, Kusnandi Rusmil^a, Irvan Afriandi^c, Lukman Ade Chandra^d, Kevin Gunawan^e

Affiliations
^aDepartment of Child Health, Faculty of Medicine, Padjadjaran University/Hasan Sadikin General Hospital, Bandung, West Java, Indonesia, ^bDepartment of Neurology, Faculty of Medicine, Padjadjaran University/Hasan Sadikin General Hospital, Bandung, West Java, Indonesia, ^cDepartment of Public Health, Faculty of Medicine, Padjadjaran University/Hasan Sadikin General Hospital, Bandung, West Java, Indonesia, ^dDepartment of Pharmacology and Therapy, Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia, ^eDepartment of General Medicine, Faculty of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia

Background

• Autism spectrum disorder (ASD) involves differences in social communication and repetitive behaviors.

• No standardized technique exists to predict functional ability in children with ASD, risking undetected impairments and delayed treatment.

Methods

• Scoping review following PRISMA criteria.

• Twelve articles met the inclusion criteria.

Key Results

• Tools and parameters that may help predict daily-life abilities in children with ASD were summarized.

• They varied widely, from clinical questionnaires and physical symptoms to laboratory tests and imaging.

Discussion & Conclusion

• The tools describe various functional abilities that are altered in ASD.

• They offer insights for assessment and intervention, but no standardized approach exists yet.

Related SDGs

SDG 3: Good Health and Well-Being – Supporting assessment and care for children with ASD

SDG 10: Reduced Inequalities – Promoting inclusion of children with neurodevelopmental conditions

Journal Information

Journal: Tzu Chi Medical Journal

DOI: https://doi.org/10.4103/tcmj.tcmj_319_24

Comparison of immunogenicity, safety, and efficacy of EVA71 vaccine in children: a systematic review and meta-analysis

by gita sonia | Sep 22, 2026 | Artikel, SDG 3, SDGS

Authors
Muhammad Gilang Dwi Putra^a, Rodman Tarigan Girsanga, Rais Amaral Haq^b, Teuku Fais Duta^c, Frengki Prabowo Saputro Wijayanto^d, Artha Maressa Theodora Simanjuntak^d, Eddy Fadlyana^a and Kusnandi Rusmil^a

Affiliations
^aClinical Research Unit, Child Health Department, Faculty of Medicine Universitas Padjadjaran, Bandung, Indonesia; bMedical Education Study Program, Faculty of Medicine, Universitas Lampung, Bandar Lampung, Indonesia; ^cMedical Education Study Program, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia; ^dMedical Education Study Program, Faculty of Medicine Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia

Background

• Enterovirus 71 (EV-A71) is a principal cause of hand, foot, and mouth disease (HFMD) and can lead to severe neurological complications in children.

• Inactivated EV-A71 vaccines have been introduced.

Methods

• Systematic review and meta-analysis with a PROSPERO-registered protocol.

• Randomized trials in children searched via PubMed, Scopus, Cochrane, and ClinicalTrials.gov.

• Five phase III trials involving 36,659 children.

Key Results

• Vaccination significantly increased seropositivity in early, medium-term, and long-term follow-up.

• Seroconversion was significantly higher in vaccinated children (pooled RR 13.04).

• Efficacy against EV-A71-associated HFMD exceeded 98%, with mild adverse events comparable to placebo.

Discussion & Conclusion

• Inactivated EV-A71 vaccines show robust immunogenicity, high efficacy, and an acceptable safety profile.

• Future studies should explore long-term protection, booster schedules, and multivalent formulations.

Related SDGs

SDG 3: Good Health and Well-Being – Protecting children through vaccination

Journal Information

Journal: Expert Review of Vaccines

DOI: https://doi.org/10.1080/14760584.2026.2722426

Differences in cardiorespiratory fitness improvement following phase II cardiac rehabilitation program among post-coronary artery bypass grafting patients with varied risk factor profiles

by gita sonia | Sep 22, 2026 | Artikel, SDG 3

Authors

Arnengsih Nazir¹, Brandon Clementius², Badai Bhatara Tiksnadi³, Nova Sylviana⁴, Januar Wibawa Martha³

Affiliations

¹Department of Physical Medicine and Rehabilitation Medicine, Dr. Hasan Sadikin General Hospital, Faculty of Medicine Universitas Padjadjaran, Bandung, Indonesia ²Department of Medical, Ukrida Hospital, Jakarta, Indonesia ³Department of Internal Medicine/Cardiology and Vascular Medicine, Dr. Hasan Sadikin General Hospital, Faculty of Medicine Universitas Padjadjaran, Bandung, Indonesia ⁴Department of Biomedical Science, Faculty of Medicine Universitas Padjadjaran, Bandung, Indonesia

Background

• Cardiac rehabilitation supports recovery after coronary artery bypass grafting (CABG).

• This study compared fitness improvement across patients with different risk factor profiles.

Methods

• Retrospective analysis of 45 CABG patients who completed phase II cardiac rehabilitation (October 2023–March 2024).
• Risk factors: obesity, hypertension, diabetes, and dyslipidemia. Outcomes: 6-minute walk distance, maximal oxygen consumption, and metabolic equivalents.

Key Results

• The average risk factor count was 2.3 per patient; dyslipidemia was most common (73.3%).

• Fitness improved significantly in all patients and all risk factor groups.

• Patients with obesity improved significantly more than non-obese patients (p = 0.009).

Discussion & Conclusion

• Phase II cardiac rehabilitation significantly improved cardiorespiratory fitness regardless of risk factor profile.
• It should be universally recommended after CABG, with tailored interventions for patients with obesity.

Related SDGs

SDG 3: Good Health and Well-Being – Improving recovery after cardiac surgery

Journal InformationJournal: Turkish Journal of Thoracic and Cardiovascular Surgery

DOI: https://doi.org/10.5606/tgkdc.dergisi.2025.27884

fk@unpad.ac.id

Trends in adipokine-related studies in cardiovascular disease: A bibliometric analysis from 2002 to 2024

Recent Insights Into Circulating Adipokines in Obesity: Systematic Review and Meta‐Analysis

Predictors of functional ability in autism spectrum disorder: A scopingreview

Comparison of immunogenicity, safety, and efficacy of EVA71 vaccine in children: a systematic review and meta-analysis

Differences in cardiorespiratory fitness improvement following phase II cardiac rehabilitation program among post-coronary artery bypass grafting patients with varied risk factor profiles

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Humas FAKULTAS KEDOKTERAN

fk@unpad.ac.id

Jalan Ir. Soekarno KM. 21, Jatinangor - Sumedang 45363

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