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Histopathological Progression and Clinicopathologic Factors Associated with Anogenital Condyloma Acuminata: A Pathological Perspective From a Tertiary Hospital in Indonesia

by gita sonia | Sep 23, 2026 | Artikel, SDG 3, SDGS

Authors

Karimah Ihda Husnayain¹, Hermin Aminah Usman¹,Etis Primastari¹, Pati AjiAchdiat²

Affiliations

¹Department of Anatomic Pathology, Faculty of Medicine, Universitas Padjadjaran, Dr. Hasan Sadikin

Hospital, Bandung, West Java, Indonesia ²Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran, Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia

Background

• Anogenital condyloma acuminata (CA) is a benign lesion caused by low-risk HPV.

• A subset of lesions can progress histopathologically, and HIV-related immunosuppression may change their course.

Methods

• Retrospective cross-sectional study of 224 patients with histopathologically confirmed CA at Dr. Hasan Sadikin General Hospital, Bandung (2023–2024).

• Clinical, pathological, and sexual behavior data analysed with chi-square/Fisher tests and logistic regression.

Key Results

• 87 patients (38.8%) were HIV-positive.

• Bisexual orientation, lesion duration over 6 months, and lesion location were independent predictors of HIV positivity.

• Histopathological progression occurred in 13 patients (5.8%), including two squamous cell carcinomas.

Discussion & Conclusion

• HIV is highly prevalent among patients with CA.

• Routine histopathological evaluation is essential to detect malignant potential early.

Related SDGs

SDG 3: Good Health and Well-Being – Improving early detection and care for HPV- and HIV-related disease

Journal Information

Journal: Berkala Ilmu Kesehatan Kulit Dan Kelamin

DOI: https://doi.org/10.20473/bikkk.V38.1.2026.27-38

Exploring Trends in Endoscopic Dacryocystorhinostomy Research in Asia: A Bibliometric Analysis

by gita sonia | Sep 23, 2026 | Artikel, SDG 3, SDG 9, SDGS

Authors

Josiah Irma ^1,2,, Saraswati Anindita Rizki ³, Arief S. Kartasasmita ^1,4, Angga Kartiwa ⁴and Irawati Irfani ⁴

Affiliations

¹Doctoral Program in Medical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung 40161, Indonesia;

²Ophthalmology Department, Universitas Pelita Harapan, Tangerang 15810, Indonesia

³Faculty of Medicine, Universitas Pelita Harapan, Tangerang 15810, Indonesia;

⁴Ophthalmology Department, Faculty of Medicine, Universitas Padjadjaran, Bandung 40117, Indonesia;

Background

• Research trends in endoscopic dacryocystorhinostomy (Endo-DCR) across Asian countries had not been systematically mapped.

Methods

• Bibliometric analysis of the Scopus database, performed in April 2024.

• Data analysed with Microsoft Excel and VOSviewer.

Key Results

• 730 articles were included; publications rose from the early 2000s, with a surge after 2010.

• India and China were the leading contributors in Asia.

• Common keywords included endoscopy, silicone tube, and epiphora; mitomycin C, mucosal flap, and success rate were rarely used.

Discussion & Conclusion

• Endo-DCR publications grew markedly between 1972 and 2023, mostly from India and China.

• Topics such as mitomycin C, mucosal flap, laser, and success rate remain under-researched, pointing to future research opportunities.

Related SDGs

SDG 3: Good Health and Well-Being – Mapping evidence to improve surgical eye and ENT care

SDG 9: Industry, Innovation, and Infrastructure – Strengthening research and innovation through bibliometric insight

Journal Information

Journal: Surgeries

DOI: https://doi.org/10.3390/surgeries7010032

SOX2 expression in the primary tumor of castration-naive metastatic prostate adenocarcinoma in association with metastasis extent

by gita sonia | Sep 23, 2026 | Artikel, SDG 3, SDGS

Authors
Meilania Saraswati¹, Aria Kekalih², Lisnawati³, Nur Rahadiani³, Asmarinah⁴, Bethy Suryawathy Hernowo⁵, Agus Rizal Ardy Hariandy Hamid⁶, Chaidir Arif Mochtar⁶

Affiliations

¹Doctoral Program in Medical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, ²Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, ³Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, ⁴Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, ⁵Department of Anatomical Pathology Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin Hospital, Bandung, Indonesia, ⁶Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia

Background

• Poor prognosis in metastatic prostate adenocarcinoma may relate to stem cell-related genes.

• This study examined cancer stem cell markers in relation to metastasis extent.

Methods

• Cross-sectional analytical study of prostate specimens from Cipto Mangunkusumo Hospital.

• 61 patients aged 50+ (2020–2023) grouped as high-volume disease (n = 38) or low-volume disease (n = 23).

• Immunohistochemistry for CD133, CD44, SOX2, and androgen receptor, scored using H-score.

Key Results

• ISUP grade and PSA level differed significantly between high- and low-volume groups.

• SOX2 expression was significantly associated with metastatic extent.

• The low-volume group showed higher SOX2 expression in the primary tumor.

Discussion & Conclusion

• SOX2 expression in the primary tumor is linked to metastasis extent in castration-naive prostate cancer.

• Different SOX2 levels across sites and stages may reflect the cancer cells’ systemic network.

Related SDGs

SDG 3: Good Health and Well-Being – Advancing understanding of prostate cancer progression

Journal Information

Journal: Medical Journal of Indonesia

DOI: https://doi.org/10.13181/mji.oa.247588

Optimising exercise intensity for gut health: Effect on microbiota composition, barrier integrity and inflammation inmale Wistar rats

by gita sonia | Sep 23, 2026 | Artikel, SDG 3, SDGS

Authors

Nova Sylviana¹^,²^,³ Putri Karisa⁴ Nur Faizah Romadona⁵ Imam Megantara^2,6

Affiliations

¹Physiology Division, Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia ²Physiolgy Molecular Laboratory, Biology Activity Division, Central Laboratory, Universitas Padjadjaran, Sumedang, West Java, Indonesia ³Center of Sport Science, Wellness, and Longevity, Graduate School, Universitas Padjadjaran, Bandung, West Java, Indonesia ⁴Doctoral Program in Medical Science, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia ⁵Faculty of Medicine, Universitas Pendidikan Indonesia, Bandung, West Java, Indonesia ⁶Microbiology Division, Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia

Background

• Exercise influences gut microbiota and intestinal permeability, but the optimal intensity for gut health is unclear.

Methods

• Male Wistar rats were assigned to control, low (10 m/min), moderate (20 m/min), or high (30 m/min) exercise, five times a week for 8 weeks.

• qPCR measured A. muciniphila, F. prausnitzii, and E. coli; ZO-1 (barrier) and IL-6 (inflammation) mRNA were also assessed.

Key Results

• Moderate intensity increased beneficial A. muciniphila and F. prausnitzii.

• High intensity reduced them and sharply increased E. coli.

• ZO-1 rose at moderate and high intensity; IL-6 also rose, most strongly at high intensity.

Discussion & Conclusion

• Moderate exercise enhanced beneficial gut bacteria and barrier integrity.

• High-intensity exercise promoted E. coli growth and IL-6-mediated inflammation, showing a dose-dependent effect.

Related SDGs

SDG 3: Good Health and Well-Being – Promoting health through optimal physical activity

Journal Information

Journal: Experimental Physiology

DOI: https://doi.org/10.1113/EP092970

Genomic Profile of Interleukin-6 Secreting Ovarian Cancer: Validation of Future Biomarkers and Target of Therapy

by gita sonia | Sep 23, 2026 | Artikel, SDG 3, SDGS

Authors
Muhammad Ary Zucha¹^,², Vincentius Simeon Weo Budhyanto³, Widha Apriani Priadi¹, Faizah Dwi Tirtasari⁴, Moh Nailul Fahmi¹, Addin Trirahmanto¹, Ardhanu Kusumanto¹, Heru Pradjatmo¹, Siti Salima ², Ali Budi Harsono ², Gatot Nyarumenteng Adhipurnawan Winarno ², Dodi Suardi², Nadia Yasmine⁵, Agil Wahyu Wicaksono ⁶, Laurens David Paulus⁷, Muhammad Yusuf⁸, Andi Kurniadi ⁴

Affiliations

¹Department of Obstetrics and Gynecology, Division of Oncology Gynecology, Universitas Gadjah Mada – Sardjito Central Hospital, Yogyakarta, Indonesia; ²Department of Obstetrics and Gynecology, Division of Oncology Gynecology Universitas Padjadjaran-Hasan Sadikin Central Hospital, Bandung, West Java, Indonesia; ³Department of Human Genetics, Yayasan Satriabudi Dharma Setia, Tangerang, Banten, Indonesia; ⁴Department of Pathology Anatomy, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; ⁵Department of Nutrition, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; ⁶Department of Biomedical Science, Faculty of Medicine, Universitas Institut Pertanian Bogor, Bogor, West Java, Indonesia; ⁷Department of Obstetrics and Gynecology, Prof. WZ. Johanes Hospital, Nusa Tenggara Timur, Indonesia; ⁸Department of Obstetrics and Gynecology, Dharmais Central Hospital, Jakarta, Indonesia

Background

• Inflammation plays a central role in ovarian cancer, and IL-6-secreting tumors may carry altered genetic profiles.

• Studies combining IL-6 measurement with genomic profiling are lacking.

Methods

• 45 women undergoing surgery for ovarian tumors (18 malignant, 19 benign, 8 borderline).

• IL-6 was measured in serum and tumor fluid by ELISA.

• High-IL-6 cancers underwent whole-genome sequencing (ONT).

Key Results

• IL-6 levels were consistent between serum and tumor fluid.

• Malignant tumors secreted significantly more IL-6 than benign ones (p = 0.027).

• IL-6-secreting cancers showed alterations in genes including MTRF1, IL-10, IL-6, APC, PAX8, PTGS2, and PACERR.

Discussion & Conclusion

• Ovarian malignancy is marked by high secretion of pro-inflammatory cytokines.

• Inflammation may disrupt the genetic landscape, offering candidate biomarkers and therapeutic targets for future validation.

Related SDGs

SDG 3: Good Health and Well-Being – Advancing biomarker discovery in ovarian cancer

Journal Information

Journal: International Journal of Women’s Health

DOI: https://doi.org/10.2147/IJWH.S589918

fk@unpad.ac.id

Histopathological Progression and Clinicopathologic Factors Associated with Anogenital Condyloma Acuminata: A Pathological Perspective From a Tertiary Hospital in Indonesia

Exploring Trends in Endoscopic Dacryocystorhinostomy Research in Asia: A Bibliometric Analysis

SOX2 expression in the primary tumor of castration-naive metastatic prostate adenocarcinoma in association with metastasis extent

Optimising exercise intensity for gut health: Effect on microbiota composition, barrier integrity and inflammation inmale Wistar rats

Genomic Profile of Interleukin-6 Secreting Ovarian Cancer: Validation of Future Biomarkers and Target of Therapy

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Humas FAKULTAS KEDOKTERAN

fk@unpad.ac.id

Jalan Ir. Soekarno KM. 21, Jatinangor - Sumedang 45363

Humas FAKULTAS KEDOKTERAN

fk@unpad.ac.id

Jalan Ir. Soekarno KM. 21, Jatinangor - Sumedang 45363

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