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Histopathological Progression and Clinicopathologic Factors Associated with Anogenital Condyloma Acuminata: A Pathological Perspective From a Tertiary Hospital in Indonesia

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Authors

Karimah Ihda Husnayain1, Hermin Aminah Usman1,Etis Primastari1, Pati AjiAchdiat2

Affiliations

1Department of Anatomic Pathology, Faculty of Medicine, Universitas Padjadjaran, Dr. Hasan Sadikin

Hospital, Bandung, West Java, Indonesia 2Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran, Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia

Background

• Anogenital condyloma acuminata (CA) is a benign lesion caused by low-risk HPV.

• A subset of lesions can progress histopathologically, and HIV-related immunosuppression may change their course.

Methods

• Retrospective cross-sectional study of 224 patients with histopathologically confirmed CA at Dr. Hasan Sadikin General Hospital, Bandung (2023–2024).

• Clinical, pathological, and sexual behavior data analysed with chi-square/Fisher tests and logistic regression.

Key Results

• 87 patients (38.8%) were HIV-positive.

• Bisexual orientation, lesion duration over 6 months, and lesion location were independent predictors of HIV positivity.

• Histopathological progression occurred in 13 patients (5.8%), including two squamous cell carcinomas.

Discussion & Conclusion

• HIV is highly prevalent among patients with CA.

• Routine histopathological evaluation is essential to detect malignant potential early.

Related SDGs

SDG 3: Good Health and Well-Being – Improving early detection and care for HPV- and HIV-related disease

Journal Information

Journal: Berkala Ilmu Kesehatan Kulit Dan Kelamin

DOI: https://doi.org/10.20473/bikkk.V38.1.2026.27-38

gita sonia

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