Authors

Nova Sylviana^1,2,3        Putri Karisa⁴  Nur Faizah Romadona⁵  Imam Megantara^2,6

Affiliations

¹Physiology Division, Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia ²Physiolgy Molecular Laboratory, Biology Activity Division, Central Laboratory, Universitas Padjadjaran, Sumedang, West Java, Indonesia ³Center of Sport Science, Wellness, and Longevity, Graduate School, Universitas Padjadjaran, Bandung, West Java, Indonesia ⁴Doctoral Program in Medical Science, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia ⁵Faculty of Medicine, Universitas Pendidikan Indonesia, Bandung, West Java, Indonesia ⁶Microbiology Division, Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia

Background

• Exercise influences gut microbiota and intestinal permeability, but the optimal intensity for gut health is unclear.

Methods

• Male Wistar rats were assigned to control, low (10 m/min), moderate (20 m/min), or high (30 m/min) exercise, five times a week for 8 weeks.

• qPCR measured A. muciniphila, F. prausnitzii, and E. coli; ZO-1 (barrier) and IL-6 (inflammation) mRNA were also assessed.

Key Results

• Moderate intensity increased beneficial A. muciniphila and F. prausnitzii.

• High intensity reduced them and sharply increased E. coli.

• ZO-1 rose at moderate and high intensity; IL-6 also rose, most strongly at high intensity.

Discussion & Conclusion

• Moderate exercise enhanced beneficial gut bacteria and barrier integrity.

• High-intensity exercise promoted E. coli growth and IL-6-mediated inflammation, showing a dose-dependent effect.

Related SDGs

SDG 3: Good Health and Well-Being – Promoting health through optimal physical activity

Journal Information

Journal: Experimental Physiology

DOI: https://doi.org/10.1113/EP092970