Authors
Eko Fuji Ariyanto 1–3, Mohammad Parezal Lastialno4, Devina Nabila Fitri 4, Seysa Azima Arvieri4, Anastasya Kania Farahana 4, Gabriella Sachiko Jannesha Sudirman 4, Mochamad Pandu Akbar Widhiyanto4, Nur Syifa Rahmatika 2,4, Putri Prihatni Sabarina2,4, Yuni Susanti Pratiwi1,2, Gaga Irawan Nugraha 1,2, Mohammad Ghozali 1–3, Mas Rizky A A Syamsunarno1–3, Yunia Sribudiani 1–3, Yoshihiro Matsumura 5,6, Tri Hanggono Achmad1–3
Affiliations
1Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Sumedang, Indonesia; 2Cardiometabolic Working Group, Faculty of Medicine, Universitas Padjadjaran, Sumedang, Indonesia; 3Research Center for Medical Genetics, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; 4Faculty of Medicine, Universitas Padjadjaran, Sumedang, Indonesia; 5Department of Biochemistry and Metabolic Science, Akita University Graduate School of Medicine, Akita, Japan; 6Division of Metabolic Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan
Background
• Metabolic syndrome (MetS) combines obesity, hypertension, dyslipidemia, and diabetes, driving cardiovascular disease worldwide.
• Genetic predisposition and epigenetic changes interact to shape susceptibility.
Methods
• Systematic review of 55 studies published in the last decade.
• Explored genetic polymorphisms, DNA methylation, and non-coding RNAs linked to MetS.
Key Results
• MetS arises from inherited genomic risk combined with environmentally driven epigenetic reprogramming.
• DNA methylation and non-coding RNAs affect genes involved in neuroendocrine function, adipogenesis, insulin signaling, glucose and lipid metabolism, and inflammation.
Discussion & Conclusion
• Understanding these interactions may enable predictive biomarkers and targeted interventions.
• This could help reduce cardiometabolic risk.
Related SDGs
SDG 3: Good Health and Well-Being – Tackling metabolic and cardiovascular disease
Journal Information
Journal: Diabetes, Metabolic Syndrome and Obesity
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