Autors
Tetty Yuniati ¹, Fiva Aprilia Kadi ¹, Aris Primadi ¹, Dwi Oktari Erfanti ², Johanes Edy Siswanto ^3,4 and Ahmedz Widiasta ⁵,

Affiliations

¹ Neonatology Division, Child Health Department, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung 40161, Indonesia ² Neonatology Division, Child Health Department, Faculty of Medicine, Universitas Padjadjaran Hospital, Jatinangor 45363, Indonesia ³ Department of Neonatology, Harapan Kita National Woman and Children’s Hospital, Jakarta 11420, Indonesia ⁴ Faculty of Medicine, Pelita Harapan University, Tangerang 15811, Indonesia ⁵ Nephrology Division, Child Health Department, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung 40161, Indonesia

Background

• Serum creatinine, the routine marker for acute kidney injury (AKI), rises late.

• An earlier biomarker is needed, especially in neonates.

Methods

• Prospective cohort of preterm neonates (28–34 weeks’ gestation) at Hasan Sadikin General Hospital, Bandung.

• Serum NGAL and creatinine were measured, and the association with AKI in the first 48 hours was tested with Spearman’s correlation.

Key Results

• NGAL had a much higher positivity rate for early AKI (81.8%) than creatinine by KDIGO (24.7%) or nRIFLE (10.4%) criteria.

Discussion & Conclusion

• NGAL can be used as a modality to detect AKI earlier in neonates.

• Earlier detection could help protect long-term kidney health.

Related SDGs

SDG 3: Good Health and Well-Being – Improving early detection of kidney injury in newborns

Journal Information

Journal: Kidney and Dialysis

DOI: https://doi.org/10.3390/kidneydial6010014