Authors
Desi Mutiarati, Gartika Sapartini , Sri Endah Rahayuningsih, Dany Hilmanto, Eddy Fadlyana and Dedi Rachmadi

Affiliations
Department of Child Health, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin General Hospital,Bandung 40161, Indonesia

Background

• Lupus nephritis (LN) is a severe complication of childhood systemic lupus erythematosus.

• Accurate and accessible tools to assess disease activity are needed.

Methods

• Cross-sectional study of 52 children with LN at Dr. Hasan Sadikin General Hospital, Indonesia.

• SIRI and SII were calculated from complete blood counts; disease activity was scored with Mex-SLEDAI.

• Correlations were analysed with Spearman’s test.

Key Results

• Median SIRI was 1,511, median SII was 789,544, and median Mex-SLEDAI score was 7.

• SIRI correlated moderately with disease activity (r = 0.443), and SII also correlated significantly (r = 0.390).

• Both indices increased with higher LN activity.

Discussion & Conclusion

• SIRI and SII may serve as simple, non-invasive biomarkers of inflammatory activity in pediatric LN.

• Both are derived from routine blood counts, making them easy to apply in practice.

Related SDGs

SDG 3: Good Health and Well-Being – Improving monitoring of chronic disease in children

Journal Information

Journal: Children

DOI: https://doi.org/10.3390/children13040530