Authors
Meilania Saraswati¹, Aria Kekalih², Lisnawati³, Nur Rahadiani³, Asmarinah⁴, Bethy Suryawathy Hernowo⁵, Agus Rizal Ardy Hariandy Hamid⁶, Chaidir Arif Mochtar⁶

Affiliations

¹Doctoral Program in Medical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, ²Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, ³Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, ⁴Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, ⁵Department of Anatomical Pathology Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin Hospital, Bandung, Indonesia, ⁶Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia

Background

• Poor prognosis in metastatic prostate adenocarcinoma may relate to stem cell-related genes.

• This study examined cancer stem cell markers in relation to metastasis extent.

Methods

• Cross-sectional analytical study of prostate specimens from Cipto Mangunkusumo Hospital.

• 61 patients aged 50+ (2020–2023) grouped as high-volume disease (n = 38) or low-volume disease (n = 23).

• Immunohistochemistry for CD133, CD44, SOX2, and androgen receptor, scored using H-score.

Key Results

• ISUP grade and PSA level differed significantly between high- and low-volume groups.

• SOX2 expression was significantly associated with metastatic extent.

• The low-volume group showed higher SOX2 expression in the primary tumor.

Discussion & Conclusion

• SOX2 expression in the primary tumor is linked to metastasis extent in castration-naive prostate cancer.

• Different SOX2 levels across sites and stages may reflect the cancer cells’ systemic network.

Related SDGs

SDG 3: Good Health and Well-Being – Advancing understanding of prostate cancer progression

Journal Information

Journal: Medical Journal of Indonesia

DOI: https://doi.org/10.13181/mji.oa.247588