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Unraveling Hidden Risks: Unpad Study Reveals Non-Genetic Triggers Behind Severe Hypospadias

In the quiet halls of Universitas Padjadjaran’s Faculty of Medicine, Dr. Vita Indriasari and her team set out to investigate one of the most overlooked conditions affecting newborn boys—severe hypospadias. This congenital disorder, where the opening of the urethra is not located at the tip of the penis, can cause lifelong health and psychological challenges. Globally, the stakes are high: the condition impacts not only the child’s physical development but also their confidence and quality of life.

Unlike traditional assumptions that place genetics at the center of the problem, Indriasari’s case–control study shed light on non-genetic influences. Factors such as maternal age, environmental exposures, and lifestyle during pregnancy emerged as powerful determinants. The team found that advanced maternal age and maternal smoking were particularly strong contributors to severe hypospadias risk.

What makes this research crucial is its actionable outcome. “Parents can’t control genetic inheritance, but they can reduce environmental risks,” said Dr. Indriasari. With awareness, expectant mothers can avoid harmful exposures, strengthen prenatal care routines, and reduce preventable risks.

This human-centered discovery reframes the narrative: congenital disorders are not always destiny. By equipping families with knowledge, healthcare providers empower communities to intervene early. Preventive action, rooted in simple lifestyle changes, can dramatically alter outcomes for newborns.

The study speaks directly to SDG 3: Good Health and Well-Being by addressing child health at its earliest stage. It also emphasizes SDG 12: Responsible Consumption by highlighting maternal lifestyle choices. Through work like this, Unpad proves itself not only as a medical innovator but also as a champion of family health worldwide.

Tags: sdgs

Adhi Taufiq Akbar

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