Glioblastoma remains one of the deadliest brain tumors, largely resistant to conventional therapies. A multidisciplinary Indonesian research team led by Prof. Ahmad Faried explored a novel approach: leveraging the secretome of human umbilical cord mesenchymal stem cells (hUCMSCs) to target oncogenic pathways in glioma.

The study demonstrated that hUCMSC-derived secretions exert cytotoxic effects on glioblastoma cells, while simultaneously downregulating key oncogenes such as HOX, IGFBP2, EGFR, and ERK. Importantly, they enhanced Caspase-3 expression, promoting apoptosis in tumor cells.

Laboratory assays confirmed the multipotent nature of the stem cells and their ability to produce secretomes rich in growth factors and cytokines. Unlike direct cell therapies, secretome-based treatments avoid risks of uncontrolled proliferation while retaining therapeutic potency.

The implications are significant. By modulating both tumor-intrinsic genes and the tumor microenvironment, hUCMSC secretomes may offer a safer and more effective adjunct to current therapies. Moreover, this approach could circumvent the limitations posed by the blood–brain barrier, which hampers traditional drug delivery.

Although further preclinical and clinical trials are required, the findings represent a bold step toward next-generation glioblastoma therapy. Harnessing natural biological secretions, rather than synthetic drugs alone, may transform the treatment landscape for one of oncology’s most formidable challenges.

This research advances SDG 3: Good Health and Well-Being by paving the way for innovative cancer therapies, and SDG 12: Responsible Consumption and Production by promoting sustainable biomedical approaches using natural biological products. Universitas Padjadjaran’s leadership in this cutting-edge field further strengthens its global impact and standing in the THE Impact Rankings.

Endovascular aneurysm repair (EVAR) has revolutionized vascular surgery, offering reduced early mortality compared to open surgery. Yet, rare complications can turn catastrophic, as illustrated in a recent case reported by Teguh Marfen Djajakusumah and colleagues.

The case involved a 65-year-old man who developed acute limb ischemia years after EVAR. Imaging revealed massive gas formation around the endograft and thrombosis of the iliac and femoral arteries. Despite amputation and aggressive care, the infection proved uncontrollable, and the patient succumbed to sepsis.

Microbiological analysis identified antibiotic-resistant Escherichia coli as the causative pathogen. Histopathology demonstrated true vasculitis with chronic arteritis—an exceptionally rare presentation of endograft infection. The absence of replacement grafts precluded definitive surgical management, leaving only palliative amputation.

The authors stress that while endograft infections occur in less than 1% of EVAR cases, their mortality rate can exceed 70%. Early follow-up and routine imaging are essential for timely detection, as late infections may spread to adjacent arteries and cause irreversible ischemia.

This tragic case highlights both the progress and the perils of modern vascular interventions. It underscores the necessity of vigilant postoperative surveillance and rapid intervention when graft-related infections are suspected.

By raising awareness of rare but fatal complications, this study strengthens SDG 3: Good Health and Well-Being and SDG 9: Industry, Innovation, and Infrastructure, emphasizing safer and more resilient health systems. It also demonstrates Universitas Padjadjaran’s critical role in global surgical research and contributes to its advancement in the THE Impact Rankings.

Keloids represent one of the most stubborn fibroproliferative disorders in dermatology, often resistant to standard therapies. Dr. Shinta Fitri Boesoirie documented a rare case of giant auricular keloids successfully managed through a combination of surgical excision and postoperative radiotherapy.

The patient, a young adult, presented with large, disfiguring keloids on both ears that interfered with daily activities and self-esteem. Simple excision was deemed insufficient due to the high risk of recurrence. Instead, the surgical removal was immediately followed by adjuvant radiotherapy, targeting residual fibroblast activity.

Histopathological examination confirmed dense collagen deposition typical of keloids, while the radiotherapy protocol effectively minimized fibroblast proliferation. Follow-up showed excellent cosmetic results, with no significant recurrence after months of observation.

The authors stress that the management of giant keloids requires a multidisciplinary strategy, balancing functional and cosmetic concerns. By combining surgery with radiotherapy, recurrence rates—often exceeding 50% with excision alone—can be markedly reduced.

This case adds valuable evidence supporting multimodal therapy in dermatologic surgery. For patients with large, recurrent, or refractory keloids, integrating radiotherapy into postoperative care may provide the best chance for durable remission.

The work advances SDG 3: Good Health and Well-Being by improving treatment options for patients with disfiguring conditions and SDG 10: Reduced Inequalities by showing how advanced care can be applied even in resource-limited settings. Through this, Universitas Padjadjaran reinforces its role as a driver of medical progress and contributor to the THE Impact Rankings.

Chronic kidney disease patients undergoing maintenance hemodialysis frequently experience systemic inflammation, which worsens prognosis. Dr. Rudi Supriyadi and his team explored whether supplementation with reduced L-glutathione, a key antioxidant, could dampen inflammation markers in these vulnerable patients.

The trial assessed serum levels of TNF-α and hs-CRP, alongside the neutrophil-to-lymphocyte ratio (NLR), as indicators of systemic inflammation. Results demonstrated a significant reduction in all three parameters following supplementation, suggesting a promising adjunctive therapy for dialysis populations.

The biochemical rationale lies in glutathione’s central role in neutralizing free radicals and maintaining redox balance. In patients repeatedly exposed to oxidative stress from hemodialysis, restoring antioxidant capacity may directly influence inflammatory signaling pathways.

Notably, the clinical benefits extended beyond laboratory markers. Participants reported improved well-being and lower fatigue levels, though these were not the primary endpoints. Such patient-reported outcomes align with the physiological improvements observed.

These findings open new possibilities for integrating nutritional interventions into nephrology care. While larger multicenter trials are required, the study positions glutathione supplementation as a simple, low-cost approach to mitigate chronic inflammation in hemodialysis patients.

This research contributes to SDG 3: Good Health and Well-Being by enhancing quality of life and survival prospects for dialysis patients, and to SDG 12: Responsible Consumption and Production through the use of safe, sustainable nutritional interventions. It highlights Universitas Padjadjaran’s commitment to health innovation, reinforcing its standing in the THE Impact Rankings.

In reconstructive surgery, venous flaps are a crucial option but are often hampered by ischemia–reperfusion injury. A recent study led by Rani Septrina from Universitas Padjadjaran investigated how ischemic preconditioning (IPC) could improve outcomes in arterialized venous flaps, with a special focus on temperature monitoring as a predictive factor. The team explored whether brief cycles of ischemia before surgery could enhance flap survival.

The researchers designed a series of experiments in animal models, applying IPC protocols under different thermal conditions. They found that controlled hypothermia during the preconditioning phase produced a more protective effect against reperfusion injury, while normothermic settings provided less consistent results. These findings emphasize the importance of temperature as a modifiable variable during microsurgical procedures.

Interestingly, the study highlighted that ischemic preconditioning works by triggering cellular defense mechanisms, reducing oxidative stress, and preserving microvascular integrity. In the arterialized venous flap, where venous drainage is already precarious, these effects proved vital.

Temperature monitoring emerged as more than a supportive parameter—it became a predictor of flap viability. The authors argue that intraoperative thermal control could be integrated into surgical monitoring systems, offering real-time indicators of ischemic tolerance.

Ultimately, the research underscores the potential for IPC to expand the reliability of venous flaps in reconstructive microsurgery. If translated into clinical practice, such protocols could reduce complication rates, shorten hospital stays, and improve functional and aesthetic outcomes for patients.

This study contributes directly to SDG 3: Good Health and Well-Being by improving surgical safety and outcomes, while also touching on SDG 9: Industry, Innovation, and Infrastructure through the development of new surgical monitoring strategies. Universitas Padjadjaran’s work strengthens Indonesia’s visibility in global biomedical innovation and reinforces the university’s role in the THE Impact Rankings.